Alaskan Eskimos’ significantly higher rates of fatty artery plaque than the general U.S. population may be due to unhealthy lifestyle habits, researchers report in Stroke: Journal of the American Heart Association.

Researchers found that more than half of Alaskan Eskimo adults smoke, their level of physical activity has decreased from traditional levels, and their intake of saturated and trans fats, rather than heart-healthy omega 3 fatty acids (found in fish), has increased.

In the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study, researchers examined extensive medical histories, dietary surveys, blood analyses and ultrasound images of carotid arteries of more than 1,200 Eskimo adults (average age 42) in Alaskan villages to determine if signs of atherosclerosis – fatty plaque buildup – were present before symptoms occurred.

“Carotid arteries are the major arteries taking blood up to the brain,” said Roman, a professor of medicine in the cardiology division at Weill Cornell Medical College in New York, N.Y. “We looked for thickening of the lining of the arteries, called intimal-medial thickness, and whether there was evidence of plaque or fatty buildup, known as atherosclerosis.

“Since atherosclerosis is a systemic disease, if you see it in one artery of the body, there is a high likelihood that it is also present in the coronary arteries, or the heart,” Roman said.

Researchers found that the thickness of the lining of the carotid arteries was not much different in Alaskan Eskimos than in other population groups; however, Alaskan Eskimos’ rates of atherosclerosis were from 50 percent to 150 percent higher than those of the general U.S. population under the age of 65 depending on age and gender.

Traditionally, Eskimos eat a diet high in heart-healthy omega 3 fatty acids found in fish.

“However, the data in this report suggest that Alaskan Eskimos may have negated the protective effects of omega-3 fatty acids by increased rates of smoking, decreased physical activity, and increased intake of saturated and trans fats,” Roman said.

According the American Heart Association, in 2005, 23.9 percent of U.S. men and 18.1 percent of U.S. women were current cigarette smokers.

Even with a heart-healthy diet and exercise, smoking is a powerful and overwhelming stimulus for developing atherosclerosis, Roman said.

Roman said the study is patterned after other research looking at risk factors, prevalence and incidence of cardiovascular disease among American Indians.

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